BRG News

sodium hydroxide industrial applications-2

 

Sodium hydroxide is widely accepted for cleaning, sanitizing, and storing chromatography media and systems. The advantages of sodium hydroxide as a  cleaning and sanitation agent  are

  • Efficacy
  • Low cost
  • Ease of detection
  • Removal
  • Disposal
Sodium hydroxide has been shown to be effective in removing proteins and nucleic acids. It is also effective for inactivating

  • Viruses
  • Bacteria
  • Yeasts
  • Fungi
  • Endotoxins
It is common practice in industrial manufacturing to save time by adding a salt, such as sodium chloride, to the sodium hydroxide solution to combine cleaning with sanitization.
During restrictive inspections, producers of biopharmaceuticals and biological products usually give attention to cleaning and cleaning validation of chromatography resins and multiuse purification systems. Chromatographic resins must either be disposed of or sufficiently cleaned to ensure reproducibility in subsequent cycles.
Over the years, varied cleaning agents have been proposed. Once evaluating a new cleaning agent for a resin, make sure it is compatible with system components as well. Destruction of O-rings and other column components by a cleaning agent is a risk to a process.
For resins, the foremost cleaning agent is sodium hydroxide. Some reports indicate that heated sodium hydroxide is an excellent cleaning agent. Even without the heating, high concentrations of sodium hydroxide require facility and equipment evaluation and use of safety equipment to protect workers.